Mangiferin and its aglycone, norathyriol, improve glucose metabolism by activation of AMP-activated protein kinase.

作者: Fang Wang , Juming Yan , Yanfen Niu , Yan Li , Hua Lin

DOI: 10.3109/13880209.2013.814691

关键词:

摘要: Context: Mangiferin has been reported to possess antidiabetic activities. Norathyriol, a xanthone aglycone, the same structure as mangiferin, except for C-glucosyl bond. To our best knowledge, no study conducted determine and compare those two compounds on glucose consumption in vitro.

参考文章(42)
M. E. Cleasby, N. Dzamko, B. D. Hegarty, G. J. Cooney, E. W. Kraegen, J.-M. Ye, Metformin Prevents the Development of Acute Lipid-Induced Insulin Resistance in the Rat Through Altered Hepatic Signaling Mechanisms Diabetes. ,vol. 53, pp. 3258- 3266 ,(2004) , 10.2337/DIABETES.53.12.3258
Tom Hsun-Wei Huang, Qinglin Yang, Masaki Harada, Jasna Uberai, Jane Radford, George Q. Li, Johji Yamahara, Basil D. Roufogalis, Yuhao Li, Salacia oblonga root improves cardiac lipid metabolism in Zucker diabetic fatty rats: Modulation of cardiac PPAR-α-mediated transcription of fatty acid metabolic genes Toxicology and Applied Pharmacology. ,vol. 210, pp. 78- 85 ,(2006) , 10.1016/J.TAAP.2005.07.020
María Dolores Girón, Natalia Sevillano, Rafael Salto, Ali Haidour, Manuel Manzano, M.L. Jiménez, Ricardo Rueda, José M. López-Pedrosa, Salacia oblonga extract increases glucose transporter 4-mediated glucose uptake in L6 rat myotubes: role of mangiferin. Clinical Nutrition. ,vol. 28, pp. 565- 574 ,(2009) , 10.1016/J.CLNU.2009.04.018
Yi-Qing Zuo, Wei-Ping Liu, Yan-Fen Niu, Chang-Fu Tian, Ming-Jin Xie, Xi-Zhu Chen, Ling Li, Bis(α‐furancarboxylato)oxovanadium(IV) prevents and improves dexamethasone‐induced insulin resistance in 3T3‐L1 adipocytes Journal of Pharmacy and Pharmacology. ,vol. 60, pp. 1335- 1340 ,(2008) , 10.1211/JPP.60.10.0009
Cullen M. Taniguchi, Brice Emanuelli, C. Ronald Kahn, Critical nodes in signalling pathways: Insights into insulin action Nature Reviews Molecular Cell Biology. ,vol. 7, pp. 85- 96 ,(2006) , 10.1038/NRM1837
Min-Jia Tan, Ji-Ming Ye, Nigel Turner, Cordula Hohnen-Behrens, Chang-Qiang Ke, Chun-Ping Tang, Tong Chen, Hans-Christoph Weiss, Ernst-Rudolf Gesing, Alex Rowland, David E. James, Yang Ye, Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chemistry & Biology. ,vol. 15, pp. 263- 273 ,(2008) , 10.1016/J.CHEMBIOL.2008.01.013
Gökhan S. Hotamisligil, Inflammation and metabolic disorders Nature. ,vol. 444, pp. 860- 867 ,(2006) , 10.1038/NATURE05485
Gilberto Pardo Andreu, René Delgado, Jesus A. Velho, Carlos Curti, Anibal E. Vercesi, Iron complexing activity of mangiferin, a naturally occurring glucosylxanthone, inhibits mitochondrial lipid peroxidation induced by Fe2+-citrate. European Journal of Pharmacology. ,vol. 513, pp. 47- 55 ,(2005) , 10.1016/J.EJPHAR.2005.03.007
Wendy M. Mueller, Kimber L. Stanhope, Francine Gregoire, Joseph L. Evans, Peter J. Havel, Effects of metformin and vanadium on leptin secretion from cultured rat adipocytes. Obesity Research. ,vol. 8, pp. 530- 539 ,(2000) , 10.1038/OBY.2000.66
C. Yoosook, N. Bunyapraphatsara, Y. Boonyakiat, C. Kantasuk, Anti-herpes simplex virus activities of crude water extracts of Thai medicinal plants. Phytomedicine. ,vol. 6, pp. 411- 419 ,(2000) , 10.1016/S0944-7113(00)80068-9