Salacia reticulata has therapeutic effects on obesity
作者： Tsutomu Shimada , Yuichiro Nakayama , Yukiko Harasawa , Hirofumi Matsui , Hiroko Kobayashi
DOI: 10.1007/S11418-014-0845-9
关键词:
摘要: Salacia reticulata Wight (S. reticulata) is a herbal medicine used for treatment of early diabetes in Ayurvedic medicine. In previous reports, the extract S. showed preventive effects on obesity and various metabolic disorders suppressive effect differentiation premature adipocytes. The aim this research was to elucidate therapeutic efficacy 12-week-old TSOD mice with mature 3T3-L1 mice, therapy produced reduction body weight mesenteric fat accumulation, an improvement abnormal glucose metabolism, increase adiponectin level plasma. addition, mRNA expressions hormone-sensitive lipase (HSL) were increased fat. vitro experiments, suppression intracellular triacylglycerol accumulation enhancement glycerol release into medium cells. lipogenesis factor (peroxisome proliferator-activated receptor γ, lipoprotein lipase, CD36, fatty acid binding protein 4) down-regulated, while lipolysis (adipose tissue HSL) up-regulated. Moreover, enhanced expression total AMP-activated kinase α (AMPKα) phosphorylated AMPKα These findings demonstrate that has by enhancing genes suppressing through activation
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