Insulin resistance and low sympathetic nerve activity in the Tsumura Suzuki obese diabetic mouse: a new model of spontaneous type 2 diabetes mellitus and obesity
作者： Akira Takahashi , Masahiro Tabuchi , Wataru Suzuki , Shoichi Iizuka , Mitsunobu Nagata
DOI: 10.1016/J.METABOL.2006.08.007
关键词: Glucose uptake 、 Adipose tissue 、 Internal medicine 、 Insulin 、 Type 2 Diabetes Mellitus 、 Pancreatic hormone 、 Type 2 diabetes 、 Brown adipose tissue 、 Endocrinology 、 Insulin resistance 、 Medicine 、 Endocrinology, Diabetes and Metabolism
摘要: Abstract Tsumura Suzuki obese diabetic (TSOD) mouse is a new model of type 2 diabetes mellitus and obesity. The TSOD mice had hypoadiponectinemia. To assess the glucose utilization insulin sensitivity, we examined effect (1U/kg) on peripheral tissue uptake in vivo nonobese using 2-deoxy- d -[3H]glucose. rates constant basal condition without were similar tissues both strains. Insulin-stimulated by skeletal muscles adipose was diminished mice. In addition, assessed norepinephrine turnover brown adrenal epinephrine (E) content E because disturbances sympathetic activities relate to many features syndrome. these mice, rate decreased, at most one half extremely low rates. showed hypercorticosteronemia. These results suggest that have resistance nervous adrenomedullary activity, high adrenocortical which are significant mouse.
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