Water and bacteriorhodopsin: structure, dynamics, and function
作者： Norbert A. Dencher , Hans Jürgen Sass , Georg Büldt
DOI: 10.1016/S0005-2728(00)00139-0
关键词:
摘要: A wealth of information has been gathered during the past decades that water molecules do play an important role in structure, dynamics, and function bacteriorhodopsin (bR) purple membrane. Light-induced structural alterations bR as detected by X-ray neutron diffraction at low high resolution are discussed relationship to mechanism proton pumping. The analysis intermediate structures revealed photon-induced rearrangements hydrogen bonds concomitant with conformational changes chromophore protein. These observations led understanding key features pumping mechanism, especially vectoriality different modes translocation release uptake domain bR. In addition, influence via equilibrium fluctuations, which must occur adequate amplitude so energy barriers between states can be overcome.
tu-darmstadt.de
elsevier.com
sci-hub.se 参考文章(60)
M. H. Koch, N. A. Dencher, D. Oesterhelt, H. J. Plöhn, G. Rapp, G. Büldt, Time-resolved X-ray diffraction study of structural changes associated with the photocycle of bacteriorhodopsin. The EMBO Journal. ,vol. 10, pp. 521- 526 ,(1991) , 10.1002/J.1460-2075.1991.TB07978.X
Georgios Papadopoulos, Norbert A. Dencher, Giuseppe Zaccai, Georg Bu¨ldt, Water molecules and exchangeable hydrogen ions at the active centre of bacteriorhodopsin localized by neutron diffraction: Elements of the proton pathway? Journal of Molecular Biology. ,vol. 214, pp. 15- 19 ,(1990) , 10.1016/0022-2836(90)90140-H
H. J. Butt, K. Fendler, E. Bamberg, J. Tittor, D. Oesterhelt, Aspartic acids 96 and 85 play a central role in the function of bacteriorhodopsin as a proton pump. The EMBO Journal. ,vol. 8, pp. 1657- 1663 ,(1989) , 10.1002/J.1460-2075.1989.TB03556.X
Joachim Heberle, Norbert A. Dencher, Bacteriorhodopsin in ice FEBS Letters. ,vol. 277, pp. 277- 280 ,(1990) , 10.1016/0014-5793(90)80864-F
Karl Edman, Peter Nollert, Antoine Royant, Hassan Belrhali, Eva Pebay-Peyroula, Janos Hajdu, Richard Neutze, Ehud M. Landau, High-resolution X-ray structure of an early intermediate in the bacteriorhodopsin photocycle Nature. ,vol. 401, pp. 822- 826 ,(1999) , 10.1038/44623
HJ Sass, IW Schachowa, G Rapp, MHJ Koch, D Oesterhelt, NA Dencher, G Büldt, The tertiary structural changes in bacteriorhodopsin occur between M states: X-ray diffraction and Fourier transform infrared spectroscopy The EMBO Journal. ,vol. 16, pp. 1484- 1491 ,(1997) , 10.1093/EMBOJ/16.7.1484
Leonid S. Brown, Richard Needleman, Janos K. Lanyi, Functional Roles of Aspartic Acid Residues at the Cytoplasmic Surface of Bacteriorhodopsin Biochemistry. ,vol. 38, pp. 6855- 6861 ,(1999) , 10.1021/BI990101D
P.K. Rogan, G. Zaccai, Hydration in purple membrane as a function of relative humidity Journal of Molecular Biology. ,vol. 145, pp. 281- 284 ,(1981) , 10.1016/0022-2836(81)90344-2
Akio Maeda, Jun Sasaki, Yoichi Yamazaki, Richard Needleman, Janos K. Lanyi, Interaction of aspartate-85 with a water molecule and the protonated Schiff base in the L intermediate of bacteriorhodopsin: a Fourier-transform infrared spectroscopic study. Biochemistry. ,vol. 33, pp. 1713- 1717 ,(1994) , 10.1021/BI00173A013
R.M. Glaeser, J. Baldwin, T.A. Ceska, R. Henderson, Electron diffraction analysis of the M412 intermediate of bacteriorhodopsin Biophysical Journal. ,vol. 50, pp. 913- 920 ,(1986) , 10.1016/S0006-3495(86)83532-9