Rationale and experimental design for the va cooperative study of anticoagulation (warfarin) in the treatment of cancer
作者： Leo R. Zacharski , William G. Henderson , Frederick R. Rickles , Walter B. Forman , C. J. Cornell
DOI: 10.1002/1097-0142(197908)44:2<732::AID-CNCR2820440246>3.0.CO;2-Y
关键词:
摘要: Anticoagulants have been demonstrated to reduce tumor growth in certain experimental animal systems. Inhibition of clot formation interferes with and spread while enhancement coagulation promotes spread. The fact that the mechanism is commonly activated human malignancy together preliminary reports therapeutic efficacy anticoagulants suggests may be pathophysiologic significance also tumors. A VA Cooperative Study has established test hypothesis warfarin anticoagulation will modify course man. purpose this paper present rationale design for study emphasis on management anticoagulant administration cancer patients. This serves as basis forthcoming toxicity malignancy.
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