High risk of cardiovascular disease in iron overload patients

摘要: Eur J Clin Invest 2011; 41 (5): 479–486 Abstract Introduction  Iron overload (IO) is defined as an increase in storage iron, regardless of the presence or absence tissue damage. Whether increased iron stores are involved pathogenesis cardiovascular disease remains controversial. Objectives  To study insulin resistance markers, lipoprotein profile, activities anti and prooxidant enzymes cholesteryl ester transfer protein (CETP) patients with IO. Methods  Twenty male IO were compared 20 sex- age-matched controls. General biochemical parameters, paraoxonase 1, employing two substrates, paraoxon (PON) phenylacetate (ARE), lipoprotein-associated phospholipase A2 (Lp-PLA2) CETP determined. Results  showed higher levels HOMA-IR triglycerides [median (Q1–Q3)] [128 (93–193) vs. 79(51–91) mg dL−1, P < 0·0005] while lower high-density (HDL) cholesterol (mean ± SD) (41 ± 9 52 ± 10 mg dL−1, P < 0·0005) comparison Moreover, triglycerides/HDL-cholesterol [3·2 (2·0–5·1) 1·5 (1·0–1·9), ratio oxidized low-density [94 (64–103) 68 (59–70) IU L−1, P < 0·05] patient group. Although no difference was observed ARE activity, PON activity decreased [246 (127–410) 428 (263–516) nmol mL−1 min−1, P < 0·05]. In addition, Lp-PLA2 also (189 ± 31 155 ± 36% ml−1 h−1, P < 0·005; 10·1 ± 2·9 8·2 ± 2·4 μmol mL−1 h−1, P < 0·05, respectively). Associations between ferritin concentration alterations lipid metabolism found. Multiple regression analyses identified independent predictor (B = 65·9, P < 0·0001, r2 = 0·35), well (B = 3·7, r2 = 0·40) after adjusting for confounding variables. Conclusions  presented not only but metabolic that related to elevated associated high risk disease.