Effects of combined ferrous sulphate administration and exposure to static magnetic field on spatial learning and motor abilities in rats.

作者: Karima Maaroufi , Mohamed Ammari , Miryam Elferchichi , Bruno Poucet , Mohsen Sakly

DOI: 10.3109/02699052.2012.750753

关键词:

摘要: Primary objective: Occupational exposure to static magnetic fields (SMF) increases, in particular due the widespread use of Magnetic Resonance Imaging (MRI) for medical diagnosis, thus raising health concerns. This study investigated behavioural effects 128 mT SMF rats and examined hypothesis that iron supplementation (3 mg kg−1 5 days) potentiate SMF.Methods: Spatial learning abilities water maze, motor co-ordination rotarod skills stationary beam suspending string tests were assessed iron-treated, SMF-exposed co-exposed SMF–iron rats.Results: Acquisition maze navigation task was unaffected all groups. iron-treated showed a deficit 7-day retention test. No found suspended Only impaired A combination treatments did not produce additional degradation performa...

参考文章(34)
Hong Cz, Static magnetic field influence on human nerve function. Archives of Physical Medicine and Rehabilitation. ,vol. 68, pp. 162- ,(1987)
John F. Schenck, Safety of Strong, Static Magnetic Fields Journal of Magnetic Resonance Imaging. ,vol. 12, pp. 2- 19 ,(2000) , 10.1002/1522-2586(200007)12:1<2::AID-JMRI2>3.0.CO;2-V
A. Fredriksson, N. Schröder, T. Archer, Neurobehavioural deficits following postnatal iron overload: I spontaneous motor activity. Neurotoxicity Research. ,vol. 5, pp. 53- 76 ,(2003) , 10.1007/BF03033373
Denesa R. Lockwood, Bumsup Kwon, James C. Smith, Thomas A. Houpt, Behavioral effects of static high magnetic fields on unrestrained and restrained mice. Physiology & Behavior. ,vol. 78, pp. 635- 640 ,(2003) , 10.1016/S0031-9384(03)00040-4
Karima Maaroufi, Mohamed Ammari, Mustapha Jeljeli, Vincent Roy, Mohsen Sakly, Hafedh Abdelmelek, Impairment of emotional behavior and spatial learning in adult Wistar rats by ferrous sulfate Physiology & Behavior. ,vol. 96, pp. 343- 349 ,(2009) , 10.1016/J.PHYSBEH.2008.10.019
Allan H. Frey, Electromagnetic field interactions with biological systems. The FASEB Journal. ,vol. 7, pp. 272- 281 ,(1993) , 10.1096/FASEBJ.7.2.8440406
Jolanta Jajte, Janina Grzegorczyk, Marek Zmyślony, Elżbieta Rajkowska, Effect of 7 mT static magnetic field and iron ions on rat lymphocytes: apoptosis, necrosis and free radical processes. Bioelectrochemistry. ,vol. 57, pp. 107- 111 ,(2002) , 10.1016/S1567-5394(02)00059-2
T.J. Sobotka, P. Whittaker, J.M. Sobotka, R.E. Brodie, D.Y. Wander, M. Robl, M. Bryant, C.N. Barton, Neurobehavioral dysfunctions associated with dietary iron overload Physiology & Behavior. ,vol. 59, pp. 213- 219 ,(1996) , 10.1016/0031-9384(95)02030-6
T. Archer, N. Schoröder, A. Fredriksson, Neurobehavioural deficits following postnatal iron overload: II Instrumental learning performance. Neurotoxicity Research. ,vol. 5, pp. 77- 94 ,(2003) , 10.1007/BF03033374