Developmental toxicity evaluation of Pimenta pseudocaryophyllus (Gomes) Landrum, (E)-methyl isoeugenol chemotype, in Wistar rats.

摘要: Background Pimenta pseudocaryophyllus (Gomes) Landrum (Myrtaceae) has been traditionally used in Brazilian folk medicine. Studies have established the botanical characterization, phytochemistry profile, and pharmacological potential of this species, including antibiotic, anxiolytic, antidepressant, antioxidant, antinociceptive, anti-inflammatory properties. Despite its widespread use, no previous study conducted regarding toxicological especially during pregnancy. Thus, investigated developmental toxicity dry leaf extract P. pseudocaryophyllus, (E)-methyl isoeugenol chemotype, rats. Methods First, was prepared by a spray-drying technique. Then, pregnant Wistar rats were orally treated with at doses 0, 2000, 2500, or 3000 mg/kg from gestational day 6 through 15 (organogenesis period). On 21, underwent cesarean sections reproductive outcomes biochemistry parameters related to hepatic renal markers evaluated. Additionally, fetuses examined for external skeletal variations malformations. Results The technique preserved phytocomplex components showed satisfactory yield. No relevant differences seen food consumption, performances, biochemical between groups. However, there decrease body weight gain dams organogenesis period an increase minor offspring (increased fetal incidences only delayed ossification metacarpals, metatarsals, phalanges, sternebra, rudimentary ribs) extract. Conclusion The low maternal induced offspring. Birth Defects Research, 2017.© 2017 Wiley Periodicals, Inc.