The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins.

摘要: The c-ets protooncogenes have recently been shown to code for transcription factors that activate the oncogene responsive unit of polyoma virus enhancer. We show stromelysin gene, which is highly expressed in transformed cells and tumours, efficiently activated by c-Ets-1 -2 through two DNA elements. distal element a conserved palindrome composed strong binding sites c-Ets-1. proximal does not bind c-Ets-1, but may be indirectly increased synthesis c-Jun c-Fos. Both ets elements mediate activation oncoproteins Ha-Ras, v-Src v-Mos. These results suggest c-Ets participates mechanisms gene expression deregulated tumours.