Aberrant DNA methylation impacts gene expression and prognosis in breast cancer subtypes
作者： Balázs Győrffy , Giulia Bottai , Thomas Fleischer , Gyöngyi Munkácsy , Jan Budczies
DOI: 10.1002/IJC.29684
关键词:
摘要: DNA methylation has a substantial impact on gene expression, affecting the prognosis of breast cancer (BC) patients dependent molecular subtypes. In this study, we investigated prognostic relevance expression genes reported as aberrantly methylated, and link between in BC The value 144 methylated was evaluated ER+/HER2−, HER2+, ER−/HER2− subtypes, meta-analysis two large transcriptomic cohorts (n = 1,938 n = 1,640). correlation distinct regions also an independent dataset 104 BCs. Survival Pearson analyses were computed for each separately. 48 significantly associated with (p < 0.05), 32 these exhibited direct expression–methylation correlation. several immune-related genes, including CD3D HLA-A, both relapse-free survival (HR = 0.42, p = 3.5E-06; HR = 0.35, p = 1.7E-08) overall (HR = 0.50, p = 5.5E-04; HR = 0.68, p = 4.5E-02) ER-/HER2- On overall, distribution positive negative have different effects This large-scale allowed identification consistently prognosis, whose could represent promising biomarker prognostication clinical stratification
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