Interleukin-7 Induces Osteoclast Formation via STAT5, Independent of Receptor Activator of NF-kappaB Ligand.
作者： Jin-Hee Kim , Ji Hyun Sim , Sunkyung Lee , Min A. Seol , Sang-Kyu Ye
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摘要: … by RANKL. We discovered that activation of Akt and Erk was common to RANKL and IL-7, whereas activation of STAT5 was unique to IL-7 (Figures 5A,B), suggesting that STAT5 could …
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Jiayun Shen, Qing Shang, Lai-Shan Tam, Targeting inflammation in the prevention of cardiovascular disease in patients with inflammatory arthritis Translational Research. ,vol. 167, pp. 138- 151 ,(2016) , 10.1016/J.TRSL.2015.05.006
M. Neale Weitzmann, Simone Cenci, Leonard Rifas, Christopher Brown, Roberto Pacifici, Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines Blood. ,vol. 96, pp. 1873- 1878 ,(2000) , 10.1182/BLOOD.V96.5.1873.H8001873_1873_1878
Lynett Danks, Noriko Komatsu, Matteo M Guerrini, Shinichiro Sawa, Marietta Armaka, George Kollias, Tomoki Nakashima, Hiroshi Takayanagi, RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation. Annals of the Rheumatic Diseases. ,vol. 75, pp. 1187- 1195 ,(2016) , 10.1136/ANNRHEUMDIS-2014-207137
J. A G van Roon, S. A Y Hartgring, M. Wenting-van Wijk, K. M G Jacobs, P.-P. Tak, J. W J Bijlsma, F. P J G Lafeber, Persistence of interleukin 7 activity and levels on tumour necrosis factor alpha blockade in patients with rheumatoid arthritis. Annals of the Rheumatic Diseases. ,vol. 66, pp. 664- 669 ,(2007) , 10.1136/ARD.2006.062547
Ilaria Roato, Giacomina Brunetti, Eva Gorassini, Maria Grano, Silvia Colucci, Lisa Bonello, Lucio Buffoni, Roberto Manfredi, Enrico Ruffini, Davide Ottaviani, Libero Ciuffreda, Antonio Mussa, Riccardo Ferracini, IL-7 Up-Regulates TNF-α-Dependent Osteoclastogenesis in Patients Affected by Solid Tumor PLOS ONE. ,vol. 1, pp. 1- 7 ,(2006) , 10.1371/JOURNAL.PONE.0000124
G. Toraldo, C. Roggia, W.-P. Qian, R. Pacifici, M. N. Weitzmann, IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor κB ligand and tumor necrosis factor α from T cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 125- 130 ,(2003) , 10.1073/PNAS.0136772100
Qiong Jiang, Wen Qing Li, Francesca B. Aiello, Renata Mazzucchelli, Benyam Asefa, Annette R. Khaled, Scott K. Durum, Cell biology of IL-7, a key lymphotrophin Cytokine & Growth Factor Reviews. ,vol. 16, pp. 513- 533 ,(2005) , 10.1016/J.CYTOGFR.2005.05.004
WS Simonet, DL Lacey, CR Dunstan, MCMS Kelley, M-S Chang, R Lüthy, HQ Nguyen, S Wooden, L Bennett, T Boone, G Shimamoto, M DeRose, R Elliott, A Colombero, H-L Tan, G Trail, J Sullivan, E Davy, N Bucay, L Renshaw-Gegg, TM Hughes, D Hill, W Pattison, P Campbell, S Sander, G Van, J Tarpley, P Derby, RAEP Lee, WJ Boyle, None, Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density Cell. ,vol. 89, pp. 309- 319 ,(1997) , 10.1016/S0092-8674(00)80209-3
Miklos Tunyogi-Csapo, Katalin Kis-Toth, Marianna Radacs, Balint Farkas, Joshua J. Jacobs, Alison Finnegan, Katalin Mikecz, Tibor T. Glant, Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: Fibroblast-mediated pathologic bone resorption Arthritis & Rheumatism. ,vol. 58, pp. 2397- 2408 ,(2008) , 10.1002/ART.23653
L.C Hofbauer, D.L Lacey, C.R Dunstan, T.C Spelsberg, B.L Riggs, S Khosla, Interleukin-1β and tumor necrosis factor-α, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells Bone. ,vol. 25, pp. 255- 259 ,(1999) , 10.1016/S8756-3282(99)00162-3