HBXIP overexpression is correlated with the clinical features and survival outcome of ovarian cancer.

摘要: Accumulated evidence has demonstrated that Mammalian hepatitis B X-interacting protein (HBXIP) broad roles in cancer. Although HBXIP is associated with a variety of cancers, the expression level and its clinical significance ovarian cancer have not yet been determined. The aim this study to investigate association between clinicopathological features patients determine whether may be correlated poor prognosis patients. was assessed well-characterized series tissue samples (n = 120) long-term follow-up, using immunohistochemistry location pattern localization detected SKOV-3 cells immunofluorescence (IF) staining. relationship high analyzed by Chi-square Fisher’s exact test. Overall survival (OS) rates all were calculated Kaplan-Meier method, univariate multivariate analyses performed Cox proportional hazards regression model. IF staining revealed strongly positive signals for both cytoplasm nucleus, but mainly cells. High predominantly observed tissues adjacent non-tumor tissues. rate 60.0% (72/120) significantly higher than (17.4%, 4/23) (P = 0.000). positively occurrence lymph node metastases (P = 0.025), histological grade (P = 0.036) stage (P = 0.003). had lower overall rates. Moreover, analysis indicated HBXIP, addition stage, significant independent prognostic factor High-level progression an effective biomarker evaluation as well potential molecular therapy target