The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.
作者： Fabao Liu , Weiying Zhang , Xiaona You , Yunxia Liu , Yinghui Li
关键词:
摘要: The glucose metabolism reprogramming is a hallmark of cancer. oncoprotein hepatitis B X-interacting protein (HBXIP) functions in the development breast In this study, we supposed that HBXIP might be involved We showed led to increases generation intracellular and lactate, as well decreases reactive oxygen species. Expression synthesis cytochrome c oxidase 2 (SCO2) pyruvate dehydrogenase alpha 1 (PDHA1), two factors metabolic switch from oxidative phosphorylation aerobic glycolysis, was suppressed by HBXIP. addition, miR-183/182 miR-96 directly inhibited expression SCO2 PDHA1 through targeting their mRNA coding sequences (CDSs), respectively. Interestingly, elevated miR-183/96/182 cluster hypoxia-inducible factor 1α (HIF1α). stability HIF1α enhanced disassociating interaction von Hippel-Lindau (pVHL) with HIF1α. Moreover, miR-183 increased levels CDS VHL mRNA, forming feedback loop HIF1α/miR-183/pVHL/HIF1α. function, HBXIP-elevated vitro. HBXIP-triggered promoted growth cancer vivo. Thus, conclude enhances suppressing
impactjournals.com参考文章(48)
Qian Liu, Xiao Bai, Hang Li, Yingyi Zhang, Yu Zhao, Xiaodong Zhang, Lihong Ye, None, The oncoprotein HBXIP upregulates Lin28B via activating TF II D to promote proliferation of breast cancer cells International Journal of Cancer. ,vol. 133, pp. 1310- 1322 ,(2013) , 10.1002/IJC.28154
Shi-Wei Huang, Jun-Kai Kao, Chun-Ying Wu, Sin-Ting Wang, Hsin-Chen Lee, Shu-Mei Liang, Yi-Ju Chen, Jeng-Jer Shieh, Targeting Aerobic Glycolysis and HIF-1α Expression Enhance Imiquimod-induced Apoptosis in Cancer Cells Oncotarget. ,vol. 5, pp. 1363- 1381 ,(2014) , 10.18632/ONCOTARGET.1734
Yingyi Zhang, Yu Zhao, Hang Li, Yinghui Li, Xiaoli Cai, Yu Shen, Hui Shi, Leilei Li, Qian Liu, Xiaodong Zhang, Lihong Ye, None, The Nuclear Import of Oncoprotein Hepatitis B X-interacting Protein Depends on Interacting with c-Fos and Phosphorylation of Both Proteins in Breast Cancer Cells Journal of Biological Chemistry. ,vol. 288, pp. 18961- 18974 ,(2013) , 10.1074/JBC.M113.458638
Cho-Rok Jung, Kyung-Sun Hwang, Jinsang Yoo, Won-Kyung Cho, Jin-Man Kim, Woo Ho Kim, Dong-Soo Im, E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis. Nature Medicine. ,vol. 12, pp. 809- 816 ,(2006) , 10.1038/NM1440
Keiji Tanimoto, Yuichi Makino, Teresa Pereira, Lorenz Poellinger, Mechanism of regulation of the hypoxia‐inducible factor‐1α by the von Hippel‐Lindau tumor suppressor protein The EMBO Journal. ,vol. 19, pp. 4298- 4309 ,(2000) , 10.1093/EMBOJ/19.16.4298
S Zhang, C Shan, G Kong, Y Du, L Ye, X Zhang, MicroRNA-520e suppresses growth of hepatoma cells by targeting the NF-κB-inducing kinase (NIK) Oncogene. ,vol. 31, pp. 3607- 3620 ,(2012) , 10.1038/ONC.2011.523
Peter Staller, Jitka Sulitkova, Joanna Lisztwan, Holger Moch, Edward J. Oakeley, Wilhelm Krek, Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL Nature. ,vol. 425, pp. 307- 311 ,(2003) , 10.1038/NATURE01874
Liron Bar-Peled, Lawrence D. Schweitzer, Roberto Zoncu, David M. Sabatini, Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1 Cell. ,vol. 150, pp. 1196- 1208 ,(2012) , 10.1016/J.CELL.2012.07.032
Christopher J. Schofield, Peter J. Ratcliffe, Oxygen sensing by HIF hydroxylases Nature Reviews Molecular Cell Biology. ,vol. 5, pp. 343- 354 ,(2004) , 10.1038/NRM1366
Karen H. Vousden, Kevin M. Ryan, p53 and metabolism Nature Reviews Cancer. ,vol. 9, pp. 691- 700 ,(2009) , 10.1038/NRC2715