HBXIP over expression as an independent biomarker for cervical cancer
作者： Nan Li , Yixuan Wang , Shuanlong Che , Yang Yang , Junjie Piao
DOI: 10.1016/J.YEXMP.2017.01.009
关键词:
摘要: Abstract Background Emerging evidence demonstrated that hepatitis B virus X-interacting protein (HBXIP) has broad roles in cancers. However, high-level expression of HBXIP been correlated with human malignancies, suggesting carcinogenesis and tumor progression. The aim the study is to investigate role mechanism oncogene correlation clinicopathological status cervical Methods A total 107 cancer patients strict follow-up, 105 intraepithelial neoplasia (CIN) 31 normal epithelia samples were selected for immunohistochemical (IHC) staining protein. Additionally, cell line SiHa was included this study. relationship between characteristics analyzed verify clinical value patient prognosis, survival rates calculated using Kaplan-Meier method. Results showed a mainly cytoplasmic pattern cancers by IHC paraffin embedded tissues IF cells. strongly positive rate significantly higher SCCs CINs than epithelia. over-expression stage, differentiation, lymph node metastasis, HPV infection, P63 overall cancer. All these data defined involved progression detailed need further Conclusions appears associate progression, may potentially be used as biomarker early diagnosis, prognostic evaluation therapeutic target
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