High-Grade Cervical Lesions Among Women Attending A Reference Clinic In Brazil: Associated Factors And Comparison Among Screening Methods

摘要: Background Although screening for cervical cancer is recommended women in most countries, the incidence of greater developing countries. Our goal was to determine prevalence and factors associated with high-grade lesions/cervical among attending a reference clinic Brazil evaluate correlation histology cytology, colposcopy high-risk HPV (HR-HPV) tests. Methods A cross-sectional study carried out. The patients were interviewed collect demographic, epidemiological clinical data. Specimens collected Chlamydia trachomatis testing using Hybrid Capture (HC) PCR tests. Colposcopy performed all biopsy when cell abnormalities or intraepithelial neoplasia (CIN) present. Results total 291 participated study. median age 38 years (DIQ: 30–48 years). histologically confirmed 18.2% (95%, CI: 13.8%–22.6%), 48 (16.5%) cases CIN-2/CIN-3 5 (1.7%) invasive carcinoma. In final logistic regression model, ages between 30 49 old [OR = 4.4 (95%: 1.01–19.04), history smoking 2.4 1.14–5.18)], practice anal intercourse 1.10–5.03)] having positive HC test HR-HPV 11.23 4 0.79–26, 36)] remained independently cancer. A 64.7% CIN-3\Ca situ related HPV-16. Non-oncogenic only found CIN-1 results. Compared histology, sensitivity cytology 31.8%, specificity 95.5%; 51.0%, 91.4% concordance high. Conclusions The results confirm an association precursor lesions These data emphasize that cytological detect still important some regions should be included screening.