Systemic analysis of PPARγ in mouse macrophage populations reveals marked diversity in expression with critical roles in resolution of inflammation and airway immunity.

摘要: Although peroxisome proliferator-activated receptor γ (PPARγ) has anti-inflammatory actions in macrophages, which macrophage populations express PPARγ vivo and how it regulates tissue homeostasis the steady state during inflammation remains unclear. We now show that lung spleen macrophages selectively expressed among resting macrophages. In addition, Ly-6Chi monocytes recruited to an inflammatory site induced as they differentiated When was absent Ly-6Chi–derived initiation of response unaffected, but full resolution failed, leading chronic leukocyte recruitment. Conversely, activation favored a PPARγ-dependent manner. state, deficiency red pulp did not induce overt spleen. By contrast, deletion mild pulmonary at surprisingly precipitated mortality upon infection with Streptococcus pneumoniae. This accelerated associated impaired bacterial clearance inability sustain locally. Overall, we uncovered critical roles for promoting maintaining functionality where plays pivotal role supporting host defense. this work identifies specific potential targets agonists.