Idiosyncratic Drug-Induced Liver Injury Is Associated With Substantial Morbidity and Mortality Within 6 Months From Onset

摘要: Background & Aims Little is known about the incidence of drug-induced liver injury (DILI) and risk factors for adverse outcomes. We evaluated short-term outcomes a large cohort patients with DILI enrolled in an ongoing multicenter prospective study. Methods Data were collected from 660 adults definite, highly likely, or probable DILI. Regression methods used to identify early liver-related death transplantation chronic injury. Results Patients' median age was 51.4 years; 59.5% female 59.1% required hospitalization. Within 6 months onset, 30 received transplants (4.5%; 95% confidence interval [CI], 3.0%–6.1%) 32 died (5%; CI, 3.2%–6.5%); 53% deaths related. Asian race, absence itching, lung disease, low serum albumin levels, platelet counts, high levels alanine aminotransferase total bilirubin at presentation independent reduced times (C-statistic = 0.87). At after 18.9% 598 evaluable subjects had persistent damage. African-American higher alkaline phosphatase, prior heart disease malignancy requiring treatment 0.71). Conclusions Nearly 1 10 die undergo within onset nearly 5 remaining have evidence months. The profile presentation, initial severity, patient's medical comorbidities are important determinants likelihood death/transplantation