Hepatologische Probleme beim Intensivpatienten und eventuelle Langzeitfolgen

作者: Zollner G

DOI:

关键词:

摘要: Hepatic Dysfunction in the Intensive Care Unit. Liver dysfunction is a common finding patients on intensive care units (ICU). Elevated bilirubin marker for poor prognosis these patients. Ischemic hepatitis (also know as shock liver) caused by hypoxia hemodynamically unstable patient. This disorder characterized markedly elevated transaminases absence of other causes liver disease. The presence ischemic associated with outcome and predisposes to multiple organ failure. Survival sepsis-induced cholestasis also reduced. therapeutic approach both disorders limited therapy underlying A recently recognized cause secondary sclerosing cholangitis critically ill patient (SSC-CIP). considered be consequence bile duct leading damage finally causing failure majority SSC-CIP transplantation only established selected Other or jaundice ICU include acalculous cholecystitis, drug-induced injury, obstructive postoperative damage. Jaundice indirect hyperbilirubinemia commonly erythrocyte transfusions. Correct fast diagnosis hepatic diseases crucial J Gastroenterol Hepatol Erkr 2015; 13 (2): 7–10.

参考文章(8)
A. Drolz, T. Horvatits, K. Roedl, V. Fuhrmann, Schockleber und Cholestase beim kritisch Kranken Medizinische Klinik. ,vol. 109, pp. 228- 234 ,(2014) , 10.1007/S00063-013-0320-5
Michael Fuchs, Arun J. Sanyal, Sepsis and Cholestasis Clinics in Liver Disease. ,vol. 12, pp. 151- 172 ,(2008) , 10.1016/J.CLD.2007.11.002
Thomas Horvatits, Michael Trauner, Valentin Fuhrmann, Hypoxic liver injury and cholestasis in critically ill patients Current Opinion in Critical Care. ,vol. 19, pp. 128- 132 ,(2013) , 10.1097/MCC.0B013E32835EC9E6
Robert J Fontana, Paul H Hayashi, Jiezhun Gu, K Rajender Reddy, Huiman Barnhart, Paul B Watkins, Jose Serrano, William M Lee, Naga Chalasani, Andrew Stolz, Timothy Davern, Jayant A Talwakar, DILIN Network, Idiosyncratic Drug-Induced Liver Injury Is Associated With Substantial Morbidity and Mortality Within 6 Months From Onset Gastroenterology. ,vol. 147, pp. 96- 108 ,(2014) , 10.1053/J.GASTRO.2014.03.045
Peter Recknagel, Falk A. Gonnert, Martin Westermann, Sandro Lambeck, Amelie Lupp, Alain Rudiger, Alex Dyson, Jane E. Carré, Andreas Kortgen, Christoph Krafft, Jürgen Popp, Christoph Sponholz, Valentin Fuhrmann, Ingrid Hilger, Ralf A. Claus, Niels C. Riedemann, Reinhard Wetzker, Mervyn Singer, Michael Trauner, Michael Bauer, Liver Dysfunction and Phosphatidylinositol-3-Kinase Signalling in Early Sepsis: Experimental Studies in Rodent Models of Peritonitis PLoS Medicine. ,vol. 9, pp. e1001338- ,(2012) , 10.1371/JOURNAL.PMED.1001338
Cornelia M Gelbmann, Petra Rümmele, Monika Wimmer, Ferdinand Hofstädter, Björn Göhlmann, Esther Endlicher, Frank Kullmann, Julia Langgartner, Jürgen Schölmerich, Ischemic-like cholangiopathy with secondary sclerosing cholangitis in critically ill patients. The American Journal of Gastroenterology. ,vol. 102, pp. 1221- 1229 ,(2007) , 10.1111/J.1572-0241.2007.01118.X
C. Jaeger, G. Mayer, R. Henrich, L. Gossner, T. Rabenstein, A. May, E. Guenter, C. Ell, Secondary sclerosing cholangitis after long-term treatment in an intensive care unit: clinical presentation, endoscopic findings, treatment, and follow-up. Endoscopy. ,vol. 38, pp. 730- 734 ,(2006) , 10.1055/S-2006-925241
Gernot Zollner, Michael Trauner, Mechanisms of cholestasis. Clinics in Liver Disease. ,vol. 12, pp. 1- 26 ,(2008) , 10.1016/J.CLD.2007.11.010