Pharmacokinetics and Pharmacodynamics of Basal Insulins

摘要: Abstract The two basal insulin analogs, glargine and detemir, were developed to ameliorate the well-known limitations of NPH insulin. In contrast rapid-acting which differ exclusively in terms primary structure while sharing similar pharmacokinetics (PK) pharmacodynamics (PD), long-acting analogs are different chemical structural entities, exhibiting distinct modes protracting effect. So far, PK PD studies have often shown conflicting results, pointing out conclusions, thereby leading animated controversies. methods used evaluation insulins might been partially responsible as, although euglycemic clamp technique has broadly acknowledged be “gold standard” reference assess glucose-lowering effect an preparation, its execution interpretation substantially across studies, various methodological analytical ...