A clinical trial with Alice/R-75 strain, live attenuated serum inhibitor-resistant intranasal bivalent influenza A/B vaccine.

摘要: A clinical trial was conducted with Alice/R-75 strain live attenuated intranasal influenza A/B vaccine. With double blind control 88 adult volunteers were administered 2 doses of vaccine, 93 received one dose vaccine and placebo solution 94 subjects solution. Twenty-three other Alice monovalent For comparison, data from 21 who R-75 B in two is included. The generally well tolerated. Four-fold serum hemagglutination-inhibiting (HAI) antibody titer rises to A/England/42/72 occurred 39% the vaccinees; contrast 18% those given bivalent 11% 1 had similar four-fold HAI rises. B/Hong Kong/72 38% vaccinees, 14% 2-dose vaccinees vaccinees. An epidemic at onset study made evaluation efficacy impossible.