Clinical trial with "R-75" strain live, attenuated, serum inhibitor-resistant intranasal influenza B vaccine.
作者： J D Cherry , M J Spencer , K R Powell
DOI: 10.1128/JCM.5.6.584-587.1977
关键词:
摘要: The "R-75" strain live, attenuated, serum inhibitor-resistant influenza B vaccine was administered intranasally by drops in two doses 14 days apart to 21 volunteers. Each vaccinee paired with a close associate (roommate or workmate) who similarly received of placebo solution. Although about 50% both and recipients complained symptoms after dosage, the severity greater recipients. Fourfold hemagglutination-inhibiting antibody titer rises occurred 38% recipients, four vaccines had fourfold nasal antibody. Vaccine virus isolated from three asymptomatic There no virological serological evidence spreading
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