Steroidal contraceptive use is associated with lower bone mineral density in polycystic ovary syndrome

摘要: Polycystic ovary syndrome (PCOS) is a common condition affecting reproductive-aged women with features including hyperandrogenism and menstrual irregularity frequently treated hormonal steroidal contraceptives. Women PCOS appear to have lower bone mineral density (BMD). While contraceptives may positively affect health, their effect on BMD in not known. The aim of this study was assess according recent contraceptive use. A cross-sectional analysis 95 pre-menopausal overweight or obese sedentary [age 29.4 ± 6.4 years, body mass index (BMI) 36.1 5.3 kg/m2] who either recently took (ceased 3 months prior) were taking conducted. Clinical outcomes included BMD, anthropometry, insulin, glucose, reproductive hormones, dietary intake vitamin significantly for used compared those did (mean difference 0.06 g/cm2 % confidence interval −0.11, −0.02, p = 0.005). In regression models, independently associated use (β −0.05, CI −0.094, −0.002, 0.042), higher testosterone −0.03, −0.0008, 0.043) BMI 0.006, 0.002, 0.01, 0.007) (r2 0.22, 0.001 entire model). We report the first time that had comparison non-users independent factors known contribute BMD. Whether observation directly related other requires further investigation.