Oral contraception and other factors in relation to hospital referral for fracture. Findings in a large cohort study.

摘要: There is good evidence that estrogens and progestogens have an important effect on bone metabolism. This article explores the relationship between oral contraceptive (OC) use fractures occurring at various sites among 17,032 participants in Oxford-Family Planning Association study, which now includes information accumulated during 310,000 woman-years of observation 1968 1994. In total, 1308 women suffered least one fracture follow-up period, was largely confined to premenopausal years. When all were combined, there a modest, but highly significant trend (p < 0.001) increasing risk with total duration use. addition, statistically heterogeneity 0.01) when overall rates examined relation recency lifespan. The highest relative (1.3, 95% CI 1.1-1.5) for current or recent users; however, viewed as whole, no clear pattern apparent. Examination data individual (including lower end radius/ulna) did not provide any protective These results are closely similar those reported from Royal College General Practitioners Oral Contraception Study 1993.