Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors
作者： Kevin R. Condroski , Timothy Kercher , Jeongbeob Seo , Steven W. Andrews , Shelley Allen
DOI:
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摘要: Compounds of Formula I: or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Y, B, and Ring C are as defined herein, wherein the Y-B moiety NH-C(=X)-NH in trans configuration, inhibitors TrkA kinase useful treatment diseases which can be treated with a inhibitor such pain, cancer, inflammation, neurodegenerative certain infectious diseases.
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