Trka kinase inhibitors, compositions and methods thereof
作者： Craig A. Stump , Andrew J. Cooke , Chun Sing Li , Qinghua Mao , Xu-Fang Zhang
DOI:
关键词: Inflammation 、 Kinase 、 Internal medicine 、 Chemistry 、 Nerve growth factor 、 Protein kinase A 、 Cancer 、 Trk receptor 、 Endocrinology 、 Tropomyosin receptor kinase A 、 Psoriasis 、 Cancer research
摘要: The present invention is directed to benzyl urea compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein inhibitors, and hence may be useful in the treatment pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating dysmyelination demyelination disease disorder associated with abnormal activities nerve growth factor (NGF) receptor Trk-A, Trk-B and/or Trk-C.
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