Source Control Review in Clinical Trials of Anti-infective Agents in Complicated Intra abdominal Infections
作者： J. S. Solomkin , R. L. Ristagno , A. F. Das , J. B. Cone , S. E. Wilson
DOI: 10.1093/CID/CIT128
关键词:
摘要: In clinical trials of complicated intra-abdominal infections, assessment adequacy the initial surgical approach to management infection is considerable importance in determining outcome. Antibiotic therapy would not be expected adequately treat if procedure was inadequate with respect source control. Inclusion such cases an efficacy analysis a particular therapeutic antibiotic may confound results. We analyzed control review process used double-blind antibiotics infections identified through systematic review. searched MEDLINE (PubMed) and ClinicalTrials.gov databases identify relevant articles reporting results from that process. Eight prospective, randomized, doubleblind, multicenter, 5 anti-infective agents provide recommendations for independent, adjudicated applicable future trials.
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