Integrins in Angiogenesis

摘要: Angiogenesis, the formation of new blood vessels from pre-existing vessels, plays a prominent role in variety pathological conditions, including tumor growth, ocular disease and arthritis. Endothelial cell adhesion to extracellular matrix (ECM) permits transduction signals initiated by angiogenic growth factors leading activation distinct signaling pathways that promote endothelial proliferation, migration/invasion survival. Integrins play pivotal promoting transfer chemical mechanical environment into intracellular compartment. Here, we review recent advances our understanding integrins mediating invasion, migration, importantly, their regulating survival invasive cells as they encounter microenvironments. Progress use integrin antagonists antiangiogenic agents clinic will be summarized.