Preparation of recombinant vaccines

摘要: Vaccination is one of the most efficient ways to eradicate some infectious diseases in humans and animals. The material traditionally used as vaccines attenuated or inactivated pathogens. This approach sometimes limited by fact that for vaccination not efficient, available, generating deleterious side effects. A possible theoretical alternative use recombinant proteins from implies having capacity vaccinate have been identified they can be produced sufficient quantity at a low cost. Genetically modified organisms harboring pathogen genes fulfil these conditions. Microorganisms, animal cells well transgenic plants animals source vaccines. Each systems are all getting improved has advantages limits. Adjuvants must generally added enhance their vaccinating capacity. purified avoid any immunization against contaminants. efficiency vaccine poorly predictable. Multiple various modes administration therefore empirically evaluated on case-by-case basis. structure proteins, composition adjuvants mode strong fully predictable impact immune response protection level Recombinant theoretically also carriers epitopes other increasing knowledge genomes availability prepare large amounts greatly facilitate potential present review critical analysis state art this field.