Prostaglandin E2 production by endogenous secretion of interleukin-1 in decidual cells obtained before and after the labor

作者: Osamu Ishihara , Hitomi Numari , Masahiro Saitoh , Yoshinori Arai , Hitoshi Takanashi

DOI: 10.1016/S0090-6980(96)00097-4

关键词:

摘要: Abstract Previous reports revealed that interleukin-1(IL-1) was involved in the process of premature labor cases with intrauterine infection. However, roles cytokine normal spontaneous remain uncertain. The present studies aimed at determining involvement prostaglandin (PG)E2 production during by third trimester decidual cells. cells were obtained time delivery (NVD) and elective cesarean section (ECS). NVD produced significantly more amount PGE2 than ECS both responded to addition IL-1β increase production. A specific inhibitor cyclooxygenase-2 (COX-2), NS398, decreased basal inhibited stimulatory effect IL-1f a dose dependent manner secreted IL-1 fl contained preprocessed 31kD inside recombinant soluble human receptor (type I) not only blocked on PG secretion, but reduced These results indicate depends upon COX-2 after onset labor. Besides it seems likely endogenously may be autocrine fashion inducing

参考文章(27)
S. K. Durum, Ying King Wu, R. Romero, D. T. Brody, E. Oyarzun, G. W. Duff, Human decidua: a source of interleukin-1. Obstetrics & Gynecology. ,vol. 73, pp. 31- 34 ,(1989)
Charles R. Brinkman, Circulation in the Pregnant Uterus Uterine Function. pp. 519- 537 ,(1990) , 10.1007/978-1-4613-0575-0_18
Roberto Romero, Moshe Mazor, Rafaella Morrotti, Cecilia Avila, Enrique Oyarzun, Alvaro Insunza, Manuel Parra, Ernesto Behnke, Francisco Montiel, Gail H. Cassell, Infection and labor. VII. Microbial invasion of the amniotic cavity in spontaneous rupture of membranes at term. American Journal of Obstetrics and Gynecology. ,vol. 166, pp. 129- 133 ,(1992) , 10.1016/0002-9378(92)91845-2
Jordan D. Miller, Mary E. Carsten, Uterine function : molecular and cellular aspects Plenum Press. ,(1990)
Gregory E Rice, Shaun Patrick Brennecke, None, Molecular Aspects of Placental and Fetal Membrane Autacoids ,(1993)
Osamu Ishihara, Kikumi Matsuoka, Katsuyuki Kinoshita, Mark H.F. Sullivan, Murdoch G. Elder, Interleukin-1β-stimulated PGE2 production from early first trimester human decidual cells is inhibited by dexamethasone and progesterone Prostaglandins. ,vol. 49, pp. 15- 26 ,(1995) , 10.1016/0090-6980(94)00009-L
D. Cerretti, C. Kozlosky, B Mosley, N Nelson, K Van Ness, T. Greenstreet, C. March, Kronheim, T Druck, L. Cannizzaro, al. et, Molecular cloning of the interleukin-1 beta converting enzyme Science. ,vol. 256, pp. 97- 100 ,(1992) , 10.1126/SCIENCE.1373520
Morten Svenson, Morten Bagge Hansen, Peter Heegaard, Kathrine Abell, Klaus Bendtzen, Specific binding of interleukin 1 (IL-1)β and IL-1 receptor antagonist (IL-1ra) to human serum. High-affinity binding of IL-1ra to soluble IL-1 receptor type I Cytokine. ,vol. 5, pp. 427- 435 ,(1993) , 10.1016/1043-4666(93)90032-Z
Emmet Hirsch, Ichiko Saotome, David Hirsch, A model of intrauterine infection and preterm delivery in mice American Journal of Obstetrics and Gynecology. ,vol. 172, pp. 1598- 1603 ,(1995) , 10.1016/0002-9378(95)90503-0
S Shimonovitz, S Yagel, E Anteby, Z Finci-Yeheskel, E Y Adashi, M Mayer, A Hurwitz, Interleukin-1 stimulates prostaglandin E production by human trophoblast cells from first and third trimesters. The Journal of Clinical Endocrinology & Metabolism. ,vol. 80, pp. 1641- 1646 ,(1995) , 10.1210/JCEM.80.5.7745012