Continuous blockade of brain mineralocorticoid receptors impairs spatial learning in rats.

作者: Joyce L.W Yau , June Noble , Jonathan R Seckl

DOI: 10.1016/S0304-3940(99)00858-7

关键词:

摘要: Hippocampal mineralocorticoid receptors (MR) are proposed to mediate facilitation of cognition in the short-term. The acute central blockade of MR increases plasma …

参考文章(20)
De Kloet, Brain corticosteroid receptor balance and homeostatic control Frontiers in Neuroendocrinology. ,vol. 12, pp. 95- 164 ,(1991)
SR Bodnoff, AG Humphreys, JC Lehman, DM Diamond, GM Rose, MJ Meaney, Enduring effects of chronic corticosterone treatment on spatial learning, synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats The Journal of Neuroscience. ,vol. 15, pp. 61- 69 ,(1995) , 10.1523/JNEUROSCI.15-01-00061.1995
M S Oitzl, E R de Kloet, Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning. Behavioral Neuroscience. ,vol. 106, pp. 62- 71 ,(1992) , 10.1037//0735-7044.106.1.62
Victoria Luine, Miriam Villegas, Carlos Martinez, Bruce S. McEwen, Repeated stress causes reversible impairments of spatial memory performance Brain Research. ,vol. 639, pp. 167- 170 ,(1994) , 10.1016/0006-8993(94)91778-7
B Couette, V Marsaud, E E Baulieu, H Richard-Foy, M E Rafestin-Oblin, Spironolactone, an aldosterone antagonist, acts as an antiglucocorticosteroid on the mouse mammary tumor virus promoter. Endocrinology. ,vol. 130, pp. 430- 436 ,(1992) , 10.1210/ENDO.130.1.1309341
Anna Ratka, Winardi Sutanto, Margreet Bloemers, Ronald de Kloet, On the role of brain mineralocorticoid (type I) and glucocorticoid (type II) receptors in neuroendocrine regulation. Neuroendocrinology. ,vol. 50, pp. 117- 123 ,(1989) , 10.1159/000125210
Melly S Oitzl, Marc Fluttert, E.Ron de Kloet, Acute blockade of hippocampal glucocorticoid receptors facilitates spatial learning in rats. Brain Research. ,vol. 797, pp. 159- 162 ,(1998) , 10.1016/S0006-8993(98)00387-4
Melly S. Oitzl, Marc Fluttert, Win Sutanto, E. Ron De Kloet, Continuous blockade of brain glucocorticoid receptors facilitates spatial learning and memory in rats European Journal of Neuroscience. ,vol. 10, pp. 3759- 3766 ,(1998) , 10.1046/J.1460-9568.1998.00381.X
Mario Engelmann, Rainer Landgraf, Patrick Lörscher, Charlotte Conzelmann, Joseph C Probst, Florian Holsboer, Johannes MHM Reul, None, Downregulation of brain mineralocorticoid and glucocorticoid receptor by antisense oligodeoxynucleotide treatment fails to alter spatial navigation in rats European Journal of Pharmacology. ,vol. 361, pp. 17- 26 ,(1998) , 10.1016/S0014-2999(98)00702-X