Potential antitumor agents. part 291: synthesis and potential coanthracyclinic activity of Imidazo[2,1-b]thiazole guanylhydrazones
作者： Aldo Andreani , Alberto Leoni , Alessandra Locatelli , Rita Morigi , Mirella Rambaldi
DOI: 10.1016/S0968-0896(00)00165-6
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摘要: This paper reports the synthesis of new imidazo[2,1-b]thiazole guanylhydrazones which were tested as potential antitumor agents. Three these derivatives (those bearing a 3- or 4-nitrophenyl group) most potent and one showed mild effect CDK1 inhibitor. These same three also positive inotropic agents two them more than amrinone at 10(-5) M. could be useful coanthracyclinic
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