Mitoconfusion: noncanonical functioning of dynamism factors in static mitochondria of the heart.
作者： Moshi Song , Gerald W. Dorn
DOI: 10.1016/J.CMET.2014.12.019
关键词:
摘要: Mitochondrial fitness is central to heart health. In many cell types, mitochondria are dynamic, interconnected filamentous networks. By comparison, of healthy postmitotic adult cardiomyocytes shortened, round, hypodynamic organelles. networks absent in cardiomyocytes; fission, fusion, and organelle mobility not normally observed. Nevertheless, mitochondrial fission factor Drp1 fusion factors Mfn1, Mfn2, Opa1 abundant indispensable hearts. Here, we review recent insights into roles for dynamics strictly related morphometric remodeling, advancing the argument that cardiomyocyte support surveillance, sequestration, mitophagic removal damaged
core.ac.uk
elsevier.com
sci-hub.se 参考文章(111)
Le Chen, Qizhi Gong, James P. Stice, Anne A. Knowlton, Mitochondrial OPA1, apoptosis, and heart failure Cardiovascular Research. ,vol. 84, pp. 91- 99 ,(2009) , 10.1093/CVR/CVP181
Gerald W. Dorn, Richard N. Kitsis, The Mitochondrial Dynamism-Mitophagy-Cell Death Interactome: Multiple Roles Performed by Members of a Mitochondrial Molecular Ensemble Circulation Research. ,vol. 116, pp. 167- 182 ,(2015) , 10.1161/CIRCRESAHA.116.303554
György Szabadkai, Anna Maria Simoni, Mounia Chami, Mariusz R. Wieckowski, Richard J. Youle, Rosario Rizzuto, Drp-1-Dependent Division of the Mitochondrial Network Blocks Intraorganellar Ca2+ Waves and Protects against Ca2+-Mediated Apoptosis Molecular Cell. ,vol. 16, pp. 59- 68 ,(2004) , 10.1016/J.MOLCEL.2004.09.026
Dieter A. Kubli, Xiaoxue Zhang, Youngil Lee, Rita A. Hanna, Melissa N. Quinsay, Christine K. Nguyen, Rebecca Jimenez, Susanna Petrosyan, Anne N. Murphy, Åsa B. Gustafsson, Parkin Protein Deficiency Exacerbates Cardiac Injury and Reduces Survival following Myocardial Infarction Journal of Biological Chemistry. ,vol. 288, pp. 915- 926 ,(2013) , 10.1074/JBC.M112.411363
Torsten Doenst, Tien Dung Nguyen, E. Dale Abel, Cardiac Metabolism in Heart Failure Circulation Research. ,vol. 113, pp. 709- 724 ,(2013) , 10.1161/CIRCRESAHA.113.300376
D. Glick, W. Zhang, M. Beaton, G. Marsboom, M. Gruber, M. C. Simon, J. Hart, G. W. Dorn, M. J. Brady, K. F. Macleod, BNip3 regulates mitochondrial function and lipid metabolism in the liver. Molecular and Cellular Biology. ,vol. 32, pp. 2570- 2584 ,(2012) , 10.1128/MCB.00167-12
Moshi Song, Yun Chen, Guohua Gong, Elizabeth Murphy, Peter S. Rabinovitch, Gerald W. Dorn, Super-Suppression of Mitochondrial Reactive Oxygen Species Signaling Impairs Compensatory Autophagy in Primary Mitophagic Cardiomyopathy Circulation Research. ,vol. 115, pp. 348- 353 ,(2014) , 10.1161/CIRCRESAHA.115.304384
Anh H. Pham, Shuxia Meng, Quynh N. Chu, David C. Chan, Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit Human Molecular Genetics. ,vol. 21, pp. 4817- 4826 ,(2012) , 10.1093/HMG/DDS311
Gerald W. Dorn, Charles F. Clark, William H. Eschenbacher, Min-Young Kang, John T. Engelhard, Stephen J. Warner, Scot J. Matkovich, Casey C. Jowdy, MARF and Opa1 Control Mitochondrial and Cardiac Function in Drosophila Circulation Research. ,vol. 108, pp. 12- 17 ,(2011) , 10.1161/CIRCRESAHA.110.236745
Poonam Bhandari, Moshi Song, Yun Chen, Yan Burelle, Gerald W. Dorn, Mitochondrial Contagion Induced by Parkin Deficiency in Drosophila Hearts and Its Containment by Suppressing Mitofusin Circulation Research. ,vol. 114, pp. 257- 265 ,(2014) , 10.1161/CIRCRESAHA.114.302734