Triglyceride-lowering effect of chenodeoxycholic acid in patients with endogenous hypertriglyceridaemia.
作者： N.E. Miller , P.J. Nestel
DOI: 10.1016/S0140-6736(74)91134-9
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摘要: Abstract The effects of chenodeoxycholic acid (C.D.C.A.) therapy on plasma lipid and lipoprotein metabolism have been studied in eleven patients with hypertriglyceridaemia. Plasma-triglycerides fell significantly by 79-986 mg. per 100 ml. (25-54%) nine the patients, absolute fall being positively correlated pretreatment concentration. triglyceride-lowering effect C.D.C.A. appeared to derive from a decreased secretion into triglyceride-rich very-low-density lipoprotein. Three also demonstrated relatively smaller falls (14-28%) plasma-cholesterol. Treatment was well tolerated, although serum activities aspartate alanine amino-transferases rose slightly. Long-term clinical trials treatment hypertriglyceridaemia seem be indicated.
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