Effects of cholestyramine and chenodeoxycholic acid on the metabolism of endogenous triglyceride in hyperlipoproteinemia.

摘要: Previous studies conducted under basal conditions have suggested a linkage between the formation of plasma triglyceride and degradation cholesterol to bile acids. To further examine this relationship, endogenous kinetics were determined using [(3)H]glycerol in 26 hyperlipidemic subjects before during stimulated (cholestyramine treatment) inhibited (chenodeoxycholic acid synthesis. All patients with hyperlipoproteinemia (HLP) type II (n = 9) treated cholestyramine (12 g daily for 2-4 months) displayed increased apparent biosynthesis (12.8 +/- 1.5 vs. 9.7 1.2 micro mol kg(-1)hr(-1), mean SEM, P < 0.005) an elevated fractional turnover rate (0.230 0.017 0.176 0.014 hr(-1), 0.001) as over 10-hr period, spite essentially unchanged concentrations. No consistent effect therapy was encountered five studied IV HLP. Chenodeoxycholic feeding (1.9 mmol 3-4 resulted reduced synthesis triglycerides both IIa 5, 7.9 0.5 13.1 0.01) HLP 7, 15.5 1.8 23.6 3.7 0.02). Furthermore, 20-25% reduction seen, concentration by about 15%. It is concluded that present experimental primarily influence also affect metabolism triglycerides-and presumably very low density lipoprotein-in regulatory manner. Hypothetically, may be achieved via hepatic pool newly synthesized cholesterol.