Is Immunity to malaria really short-lived?

摘要: Protection against Plasmodium falciparum malaria is usually considered to be the cumulative product of repeated exposure parasites, and thus a function age, in endemic areas. The recent outbreak central highlands Madagascar gave Philippe Deloron Claire Chougnet opportunity compare incidence children young adults exposed for first time, with that older who spent their childhood study area before control was introduced. Protection, as well immune responses two major P. antigens, not related age. Individuals than 40 years were more protected younger adults. This increased protection probably due immunological memory.