HYPERALGESIA AND ALLODYNIA: PERIPHERAL MECHANISMS

摘要: Abstract Nociceptive signals are generated by peripheral sensory organs called nociceptors, which endings of small-diameter nerve fibers responsive to the tissue environment. The myriad chemical mediators capable activating, sensitizing, or arousing nociceptors include kinins, proinflammatory and anti-inflammatory cytokines, prostanoids, lipooxygenases, “central immune response mediator” NF-κB, neurotrophins other growth factors, neuropeptides, nitric oxide, histamine, serotonin, proteases, excitatory amino acids, adrenergic amines, opioids. These may act in combination at a given time inflammatory process, producing subtle changes that result hyperalgesia allodynia. We will review most extensively studied molecular cellular mechanisms underlying these two clinical abnormalities. role nervous system progression joint disease chronicity is discussed.