Investigation of Gastroduodenal Mucosal Injury in Japanese Asymptomatic Antiplatelet Drug Users
作者： Masahiro Sogabe , Toshiya Okahisa , Masahiko Nakasono , Yasuteru Fujino , Yasuhiro Mitsui
DOI: 10.1097/MD.0000000000001047
关键词:
摘要: Antiplatelet drugs are widely used for the prevention of cardiovascular disease and cerebral vascular disorders. Although there have been several studies on gastroduodenal mucosal injury with gastrointestinal (GI) symptoms such as GI bleeding, in antiplatelet drug users (including low-dose aspirin (LDA)), few reports association between use asymptomatic users. This study was a cross-sectional elucidating users.Subjects were 186 Japanese who underwent regular health checkup. Subjects divided into those without endoscopically, other data investigated.The prevalence males drinkers significantly higher subjects than without. In addition, proton pump inhibitor (PPI) lower injury. Logistic regression analysis showed PPI (odds ratios: 0.116; 95% confidence intervals: 0.021-0.638; P < 0.05) significant predictor decreased closed-type (C-type) atrophy (3.172; 1.322-7.609; 0.01) an increased severe users.Gender lifestyle, drinking, may impact risk taking drugs. is injury, including users, status gastric should also be considered against
sci-hub.se 参考文章(45)
A Laszlo, B E Wiholm, J P Kelly, D W Kaufman, R S Koff, S Shapiro, Alcohol consumption and the risk of major upper gastrointestinal bleeding. The American Journal of Gastroenterology. ,vol. 90, pp. 1058- 1064 ,(1995)
Kazumasa Miyake, Masafumi Kusunoki, Nobue Ueki, Hiroyuki Nagoya, Yasuhiro Kodaka, Tomotaka Shindo, Tetsuro Kawagoe, Katya Gudis, Seiji Futagami, Taku Tsukui, Hiroshi Nakamura, Choitsu Sakamoto, Implication of antithrombotic agents on potential bleeding from endoscopically determined peptic ulcers, incidentally detected as surrogate markers for nsaids-associated ulcers complication. Digestive Endoscopy. ,vol. 25, pp. 25- 31 ,(2013) , 10.1111/J.1443-1661.2012.01334.X
Luis A Garcı´ a Rodrı´ guez, Sonia Hernández‐Dı´ az, Francisco J De Abajo, Association between aspirin and upper gastrointestinal complications: Systematic review of epidemiologic studies British Journal of Clinical Pharmacology. ,vol. 52, pp. 563- 571 ,(2001) , 10.1046/J.0306-5251.2001.01476.X
Choitsu Sakamoto, Kentaro Sugano, Shinichi Ota, Nobuhiro Sakaki, Shin’ichi Takahashi, Yukio Yoshida, Taku Tsukui, Hiroyuki Osawa, Yukihiro Sakurai, Junji Yoshino, Yuji Mizokami, Tetsuya Mine, Tetsuo Arakawa, Hajime Kuwayama, Katsunori Saigenji, Koji Yakabi, Tsutomu Chiba, Tooru Shimosegawa, Jane E. Sheehan, Susana Perez-Gutthann, Takuhiro Yamaguchi, David W. Kaufman, Tsugumichi Sato, Kiyoshi Kubota, Akira Terano, Case-control study on the association of upper gastrointestinal bleeding and nonsteroidal anti-inflammatory drugs in Japan. European Journal of Clinical Pharmacology. ,vol. 62, pp. 765- 772 ,(2006) , 10.1007/S00228-006-0171-6
Akiko Shiotani, Takashi Sakakibara, Yoshiyuki Yamanaka, Hiroshi Imamura, Ken-Ichi Tarumi, Noriaki Manabe, Tomoari Kamada, Hiroaki Kusunoki, Jiro Hata, Ken Haruma, Upper gastrointestinal ulcer in Japanese patients taking low-dose aspirin Journal of Gastroenterology. ,vol. 44, pp. 126- 131 ,(2009) , 10.1007/S00535-008-2290-6
Maria Carla Roncaglioni, None, Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general Practice The Lancet. ,vol. 357, pp. 89- 95 ,(2001) , 10.1016/S0140-6736(00)03539-X
Evan R. Kokoska, Gregory S. Smith, Yashwant Deshpande, Christopher L. Rieckenberg, Thomas A. Miller, Adaptive cytoprotection induced by ethanol in human intestinal cells: role of prostaglandins and calcium homeostasis. Annals of Surgery. ,vol. 228, pp. 123- 130 ,(1998) , 10.1097/00000658-199807000-00018
Gurkirpal Singh, Gastrointestinal Tract Complications of Nonsteroidal Anti-inflammatory Drug Treatment in Rheumatoid Arthritis Archives of Internal Medicine. ,vol. 156, pp. 1530- 1536 ,(1996) , 10.1001/ARCHINTE.1996.00440130066007
Francis Ka–leung Chan, Shinya Goto, Ming–Shiang Wu, Maria Teresa B. Abola, Khay Guan Yeoh, Bambang Sutrisna, Siew Siang Chua, Varocha Mahachai, Thana Turajane, Brian Wu, Qing Yu Zeng, Kentaro Sugano, Burden of Nonsteroidal Anti-inflammatory and Antiplatelet Drug Use in Asia: A Multidisciplinary Working Party Report Clinical Gastroenterology and Hepatology. ,vol. 10, pp. 753- 760 ,(2012) , 10.1016/J.CGH.2012.03.027
Joseph R Codispoti, Frank L Lanza, Edward B Nelson, An endoscopic comparison of gastroduodenal injury with over-the-counter doses of ketoprofen and acetaminophen The American Journal of Gastroenterology. ,vol. 93, pp. 1051- 1054 ,(1998) , 10.1016/S0002-9270(98)00208-1