Neurological impairment during long-term intrathecal infusion of bupivacaine in cancer patients: a sign of spinal cord compression
作者： Robert T.M van Dongen , Rob van Ee , Ben J.P Crul
DOI: 10.1016/S0304-3959(96)03240-X
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摘要: Adequate pain relief in patients with far advanced cancer sometimes requires intrathecal (IT) administration of a combination opioids and local anesthetics. Tumor progression as well the IT anesthetics can lead to neurologic dysfunction during treatment. Five showed symptoms compression cauda equina or spinal cord shortly after start combined morphine bupivacaine dosage usually not associated symptoms. Unexpectedly, evaluation suggested cord, which was confirmed radiographically. Manifestation new low dose infusion intrathecally might therefore be an early indicator space-occupying processes within canal patients.
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