Perturbation of xenobiotic metabolism in Dreissena polymorpha model exposed in situ to surface water (Lake Trasimene) purified with various disinfectants.

摘要: Sanitation is of crucial importance for the microbiological safety drinking water. However, chlorination water rich in organic material produces disinfection by-products (DBPs), many which have been reported to be mutagenic and/or carcinogenic compounds such as haloacetic acids and trihalomethanes. Epidemiological studies suggested a link between consumption cancer. We previously observed that Cyprinus carpio fish exposed DBPs, may subject epigenetic effects those referable up-regulation cytochrome P450 (CYP) superfamily (ex. co-mutagenesis/co-carcinogenesis oxidative stress) has associated non-genotoxic carcinogenesis. Our goal was study xenobiotic metabolism mollusks situ surface Lake Trasimene (Central Italy) treated with several disinfectants traditional chlorine dioxide (ClO2), sodium hypochlorite (NaClO) or relatively new one peracetic acid (PAA). The freshwater bivalves (Dreissena polymorpha) being selected biomarker, unique ability accumulate pollutants. Freshwater were maintained containing each disinfectant individually (1-2 mg/L). Following an exposure period up 20 days during fall period, microsomes collected from mussels, then tested various monooxygenases. Strong CYP inductions observed. These data indicate generates harmful DBP mixtures capable determining marked perturbation CYP-supported reactions. This phenomenon, increased pro-carcinogen bioactivation persistent stress, could provide explanation observational connecting regular risk cancers humans.