Mood and Cognitive Changes During Systemic Corticosteroid Therapy.

摘要: BACKGROUND: Physicians in the United States write approximately 10 million new prescriptions for oral corticosteroids each year. Common side effects of include weight gain, osteoporosis, and diabetes mellitus. This article reviews available literature on psychiatric cognitive changes during corticosteroid therapy. METHOD: A search MEDLINE psycINFO databases was conducted to find clinically relevant articles with using terms including corticosteroid, prednisone, mania, depression, psychosis, mood, memory, cognition. RESULTS: Symptoms hypomania, psychosis occur therapy as do changes, particularly deficits verbal or declarative memory. Psychiatric symptoms appear be dose-dependent generally first few weeks Patients who must remain may benefit from pharmacotherapeutic approaches, such lithium antipsychotic medications. CONCLUSION: Mood common but mild reversible effects. More studies are needed determine effective treatment steroid-induced disorders.