Super Spatial Resolution (SSR) method for small animal SPECT imaging: A Monte Carlo study

摘要: Abstract This work used Monte Carlo (MC) simulations in order to investigate the feasibility of application a super-resolution method, namely Super Spatial Resolution (SSR), preclinical SPECT system. The SSR method is obtain resolution enhancement by combining several images containing slightly different perspectives same scene. MC are useful tool development new imaging devices, as well assessment reconstruction methods. In this respect, GATE (Geant4 Application for Emission Tomography) an open source platform dedicated numerical that has become validated toolkit simulation and PET systems. We modelled four-headed scanner capable proper movements acquisition sequences. Each detector based on CsI(Tl) pixelated scintillator coupled low-energy tungsten collimator with parallel square holes. Several phantoms radioactive sources were simulated, assess performance proposed scanner. addition, complex voxelized phantom mouse was realistic aim evaluating system suitable small animal imaging. whole sensitivity 164.1 cps/MBq. impact value must be divided number acquired perform method. average trans-axial improves from 2.4 mm 1.54 mm, 1.21 mm 1.03 mm respectively applying two, three or four images. While axial changes 1.69 mm 1.49 mm, 1.15 mm 0.98 mm using obtained voxel have demonstrated good capability Finally, comparison commercial scanners proved presented provides alternative pinhole systems many research studies.