Opposing Roles of D1and D2Receptors in Appetitive Conditioning

摘要: Previous studies have shown that D1receptor blockade disrupts and D2 receptor enhances long-term potentiation. These data lead to the prediction D1 antagonists will attenuate potentiate at least some types of learning. The is difficult test, however, because disruptions in either or transmission reduced locomotion, exploration, response execution are therefore likely impair learning requires behavioral responding (including exploration an environment) during episode. Under a paradigm minimizes motor requirements, rats were trained enter food compartment pellet presentation. Animals then received tone–food pairings under influence D1antagonist SCH23390 (0, 0.4, 0.8, 0.16 mg/kg) D2antagonist raclopride 0.2, 0.8 mg/kg). An additional group unpaired presentations tone food. On drug-free test day 24 hr later, animals had been (like food) showed head entries tone, whereas increased compared with vehicle controls. demonstrate that, conditioned approach paradigm, family disrupt promote learning, respectively, as predicted by effects on neuronal plasticity.