Compounds derived from doxycycline such as haptens, conjugates and antibodies thereof, and immunochemical method for detecting doxycycline

作者: Colás María Pilar Marco , Baeza Francisco Sánchez , Izquierdo Javier Adrian

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摘要: The present invention relates to compounds having the general formula (I), wherein A is selected from S, O and NH; B -COOH, -CHO, halogen, -NH 2 -SH; n an integer 1 6, use thereof as haptens, conjugates of same for obtaining antibodies, well a method detecting and/or quantifying doxycycline which uses antibodies invention.

参考文章(5)
Nuria Pastor-Navarro, Sergi Morais, Ángel Maquieira, Rosa Puchades, Synthesis of haptens and development of a sensitive immunoassay for tetracycline residues: Application to honey samples Analytica Chimica Acta. ,vol. 594, pp. 211- 218 ,(2007) , 10.1016/J.ACA.2007.05.045
Yulan Zhang, Shengxin Lu, Wei Liu, Chengbiao Zhao, Rimo Xi, Preparation of Anti-Tetracycline Antibodies and Development of an Indirect Heterologous Competitive Enzyme-Linked Immunosorbent Assay to Detect Residues of Tetracycline in Milk Journal of Agricultural and Food Chemistry. ,vol. 55, pp. 211- 218 ,(2007) , 10.1021/JF062627S
Moonsun Jeon, Jisun Kim, Ki-Jung Paeng, Sung-Woo Park, Insook Rhee Paeng, Biotin-avidin mediated competitive enzyme-linked immunosorbent assay to detect residues of tetracyclines in milk Microchemical Journal. ,vol. 88, pp. 26- 31 ,(2008) , 10.1016/J.MICROC.2007.09.001
B A Faraj, F M Ali, Development and application of a radioimmunoassay for tetracycline. Journal of Pharmacology and Experimental Therapeutics. ,vol. 217, pp. 10- 14 ,(1981)