Time-dependent in-vivo effects of interleukin-2 on neurotransmitters in various cortices: relationships with depressive-related and anxiety-like behaviour.
作者： B.D. Karrenbauer , C.P. Müller , Y.J. Ho , R. Spanagel , J.P. Huston
DOI: 10.1016/J.JNEUROIM.2011.05.011
关键词:
摘要: Abstract We investigated the impact of systemically injected IL-2 (2.5 μg/kg, i.p.) on serotonergic and dopaminergic neurotransmission in various cortical areas by in-vivo microdialysis. lastingly reduced extracellular 5-HT levels medial prefrontal (− 75%), occipital (− 70%), temporal cortices (− 45%), whereas dopamine was only moderately cortex. Based time profile, we conducted further experiments to test for acute delayed (2 h post injection) depressive-related effects systemic (0–5.0 μg/kg) a forced swim anxiety-like behaviour elevated plus-maze. had dose-dependent after but not testing, no behaviour.
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