Nasal continuous positive airway pressure (nCPAP) treatment for obstructive sleep apnea, road traffic accidents and driving simulator performance: A meta-analysis

摘要: summary We used meta-analysis to synthesize current evidence regarding the effect of nasal continuous positive airway pressure (nCPAP) on road traffic accidents in patients with obstructive sleep apnea (OSA) as well their performance driving simulator. The primary outcomes were real accidents, near miss and accident-related events Pooled odds ratios (ORs), incidence rate (IRRs) standardized mean differences (SMDs) appropriately calculated through fixed or random effects models after assessing between-study heterogeneity. Furthermore, risk (RDs) numbers needed treat (NNTs) estimated for accidents. Meta-regression analysis was performed examine moderator variables publication bias also evaluated. Ten studies (1221 patients), five (769 patients) six simulator (110 included. A statistically significant reduction (OR ¼ 0.21, 95% CI 0.12e0.35, model; IRR 0.45, 0.34e0.59, model) 0.09, 0.04 e0.21, 0.23, 0.08e0.67, observed. Likewise, a observed (SMD ¼� 1.20, 1.75 � 0.64, effects). RD 0.22 (95% 0.32 0.13, effects), NNT equal 3e8), whereas 0.47 0.69 0.25, two 1e4). For meta-regression suggested that nCPAP seemed more effective among entering higher baseline accident rates. In conclusion, all three meta-analyses demonstrated sizeable protective both life virtual environment.