Topical sulfonylurea as a novel therapy for hypertrichosis secondary to diazoxide, and potentially for other conditions with excess hair growth

摘要: It is hypothesized that a topical application of sulfonylurea drug, which can inhibit the ATP-sensitive potassium-gated channels (Kir6.X/SUR) present in human hair bulb tissues, will growth targeted manner. Diazoxide used to treat severe hypoglycemia due hyperinsulinism infancy. However, this often results hypertrichosis be enough prevent its use. blocks insulin release from pancreas by opening SUR1/Kir6.2 s-cells. also act on two skin affect growth, namely and SUR2B/Kir6.1, thus causing hypertrichosis. proposed excessive diazoxide, but not impact beneficial effects diazoxide beta cells. This approach applied rare cases Cantu syndrome, caused mutations ABCC9 (coding for SUR2) or KCNJ8 Kir6.1) characterized congenital More importantly, may effective treating other forms hirsutism, are quite common, yet very distressing patients worldwide.