Inosine Augments the Effects of a Nogo Receptor Blocker and of Environmental Enrichment to Restore Skilled Forelimb Use after Stroke

摘要: Stroke is the leading cause of disability in much world, with few treatment options available. Following unilateral stroke rats, inosine, a naturally occurring purine nucleoside, stimulates growth projections from undamaged hemisphere into denervated areas spinal cord and improves skilled use impaired forelimb. Inosine augments neurons' intrinsic potential by activating Mst3b, component signal transduction pathway through which trophic factors regulate axon outgrowth. The present study investigated whether inosine would complement effects treatments that promote plasticity other mechanisms. rat forelimb motor area, combined NEP1-40, Nogo receptor antagonist, doubled number branches extending neurons intact side compared either alone, restored rats' level reaching using forepaw to preoperative levels. Similar functional improvements were seen when was environmental enrichment (EE). latter effect associated changes gene expression layer 5 pyramidal cortex well beyond those or EE alone. now clinical trials for indications, making it an attractive candidate patients.