CLOZAPINE DRUG-DRUG INTERACTIONS : A REVIEW OF THE LITERATURE

摘要: Clozapine is often used in combination with other medications. To date, there has been no comprehensive review of drug–drug interactions involving clozapine. This summarizes published reports suspected interactions, and assesses their clinical significance. A computerized search was conducted using MEDLINE (1975–1996) to retrieve all adverse events associated the concurrent use clozapine agents. Forty-three 19 different drugs were evaluated. appeared be involved pharmacokinetic pharmacodynamic when prescribed concurrently most major classes therapeutic In general, addition medications similar pharmacological effects or side-effects may enhance these an additive possibly synergistic manner. The selective serotonin reuptake inhibitor fluvoxamine thoroughly documented while a number found implicating various benzodiazepines apparent interactions. No clozapine–drug absolutely contraindicated, but some members given class pose less risk than others © 1997 John Wiley & Sons, Ltd.