Quinine inhibits ovulation and produces oxidative stress in the ovary of cyclic Sprague-Dawley rats.
作者： Stella Chinwe Gbotolorun , Oghenevwakpeje Inikori , Olawande Damilola Bamisi , Abraham Adewale Adepoju Osinubi , Abayomi Olugbenga Okanlawon
DOI: 10.4314/AHS.V18I2.8
关键词:
摘要: Background: Quinine has been reported to possess anti-spermatogenic activities. Objectives: This study was carried out determine the effect of quinine on ovarian function in Sprague-Dawley rats. Methods: Twenty rats with regular 4-days oestrous cycle divided into 4 groups (N=5) were used. Group I received at 30 mg/kg body weight by gavage for 28 days after which they sacrificed. The ovaries excised biochemical oxidation glutathione peroxidase (GSH), superoxide dismutase (SOD), catalase and malondialdehyde (MDA). II single dose 0900 hrs day proestrus. Blood obtained 1800 hormonal assay FSH LH. animals sacrificed next morning estrus: oviducts examined ova count. Groups III IV served as controls. Results: treated recorded zero number compared control. Serum concentration LH reduced significantly group Furthermore, decreased oxidant status GSH, SOD increased MDA levels ovary control group. Conclusion: completely blocks ovulation, suppresses surge, produces oxidative stress ovary. Keywords: Quinine, ovary, LH, stress.
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