Quinine controls body weight gain without affecting food intake in male C57BL6 mice
作者： Philippe Cettour-Rose , Carole Bezençon , Christian Darimont , Johannes le Coutre , Sami Damak
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摘要: Background Quinine is a natural molecule commonly used as flavouring agent in tonic water. Diet supplementation with quinine leads to decreased body weight and food intake rats. Quinine an vitro inhibitor of Trpm5, cation channel expressed taste bud cells, the gastrointestinal tract pancreas. The objective this work determine effect diet on composition male mice, investigate its mechanism action, whether mediated through Trpm5.
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